The show revolves solely around the Eds, the other cul-de-sac children, and the Kanker sisters. Subtle hints throughout the series pointed to where the cartoon took place, as it was revealed that the cul-de-sac is in a town called Peach Creek. As similar to the Peanuts series, no adults are seen, as well as the seeming lack of any other inhabitants and any other possible relations; besides Sarah being Ed's little sister and a the running gag of Rolf and his mysterious family relations
May, Marie, and Lee are three sisters who serve as the antagonists towards the cul-de-sac and its inhabitants. Lee is the leader with curly red hair that covers her eyes, Marie has blue hair, and May is the buck-toothed blonde. They live in the nearby trailer park called Park 'n' Flush. If there is one thing that all of the kids in the cul-de-sac can agree on, it's that they all hate the Kanker Sisters. While all the Kankers like the Eds, it has been shown that May prefers Ed, Marie for Edd, and Lee for Eddy. May is voiced by Erin Fitzgerald, except Season 3, when she was voiced by Jenn Forgie, Marie is voiced by Kathleen Barr, and Lee is voiced by Janyse Jaud.
Colored by me
Mandy is an evil, heartless girl of vast intelligence and a sinister, manipulative nature. Demanding and rude, Mandy's antagonistic behavior has left her parents in trembling, quavering perpetual intimidation, and her frightening, cold nature has left her virtually fearless in times of severe supernatural danger or while being faced with menacing, bloodthirsty otherworldly monsters. Mandy's thorough emotionlessness, however, has sometimes been touched in a few scenarios, such as at one point when Billy was thought to be dead and Mandy's reaction appeared quite nervous and partially mournful. She also possesses a strong lust for power as revealed in an episode providing insight to the future of the town of Endsville, in which Mandy has enslaved all of its citizens and evolved herself into a large, anthropomorphic being resembling a giant caterpillar (a reference to the Dune book series), and Grim's abilities have helped her gain access to satisfaction of her desires. Oddly though she keeps Billy as her companion. making clones of him whenever he is killed accidenty due to his stupidity. Mandy has been known to domineer everybody around her without fear, and the few things that she likes include junk food, television, and all things dark and melancholy. She also does not appear to have a visible nose, which has been pointed out a few times throughout the series.
Throughout the series, Mandy rarely smiles, and her facial expression remains perpetually disgruntled. Mandy smiling is shown to be the end of the world; in one episode, after entering a local beauty contest against the queen bee of her classroom, it was revealed that all of reality would be humorously, psychedelically distorted, resulting in the series swapping premises with that of the animated series The Powerpuff Girls. Despite this, Mandy is seen to crack an evil sneer at the end of a few episodes, such as when she becomes the only person left on Earth, and after winning the contest which gave her a servant in Grim. Mandy also despises Billy's best friend Irwin, who is strongly infatuated with her, and it was revealed in a television special that one of her worst nightmares would be to grow into a plump, optimistic woman married to a brawny adult version of Irwin, and in another episode it was implied that Mandy harbors a mild phobia of figure skating. Her other deepest fear was shown in the episode Heartburn where she feared losing her true heart after hearing Irwin's sad story about how he was originally born to be a really bad boy, but then experienced a change of heart after his father showed him how to love and respect other people. This caused her to seriously doubt if she could withstand a change of heart and at the thought of just losing it, caused her to scream really loudly out loud. She is also scared of an extremely angry Billy and will run from him when need be.